AOD-9604

Also called AOD9604, LAT8881, Tyr-hGH (177-191), hGH fragment 176-191

Studied in:WeightMetabolic

Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use AOD-9604 or any amount of it. Talk to a clinician.

Not approved as a medicine by the FDA or EMA (as of October 2026).

Research applications

Fat metabolism and weight gain (obese rat and mouse studies)
Obesity (developer's human trials, mostly unpublished; programme discontinued)

What studies have looked at, not proven uses.

What it is

AOD-9604 is a lab-made piece of growth hormone, developed as a possible weight-loss drug. Animal studies looked at fat metabolism, but the human program was stopped and most results weren't published.

More detail

AOD-9604 is a synthetic peptide based on the tail end of human growth hormone (amino acids 177 to 191) with an extra tyrosine added at the start. It was developed in Australia as a possible obesity drug, on the idea that this part of growth hormone carries its fat-breakdown activity without its effects on growth or blood sugar. Studies in obese rats and mice reported changes in fat metabolism and weight gain. The developer ran human trials, but the obesity programme was discontinued and most of those results were not published in peer-reviewed journals, so independent human evidence is thin.

Evidence listed here

1 review
2 animal studies

Results from cells and animals often don't carry over to people. How to read peptide research

Molecular info

Class: Synthetic peptide (hGH 177-191 analog)
Length: 16 amino acids
Sequence: H-Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe-OH
Research areas: Weight, Metabolic

Growth hormone amino acids 177-191 with a tyrosine added at the start; the two cysteines form a disulfide bridge.