CJC-1295
Also called CJC 1295, CJC-1295 DAC, CJC-1295 with DAC, DAC:GRF
Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use CJC-1295 or any amount of it. Talk to a clinician.
Not approved as a medicine by the FDA or EMA (as of October 2026).
Research applications
- Days-long rise in growth hormone and IGF-1 (placebo-controlled trials in healthy adults)
- Binding to albumin to last longer in the blood (DAC linker)
- Growth in mice lacking natural GHRH
What studies have looked at, not proven uses.
What it is
CJC-1295 is a lab-made, longer-lasting version of the hormone that tells the body to release growth hormone. Two small human trials measured its effect on hormone levels. It was never approved.
More detail
CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH). It is built on the first 29 amino acids of GHRH with several substitutions plus a chemical linker, called DAC (drug affinity complex), that lets it attach to albumin in the blood. That attachment stretches its half-life from minutes to several days. In two placebo-controlled trials in healthy adults it raised growth hormone and IGF-1 levels for days after a single administration, and a mouse study examined growth in animals lacking natural GHRH. It never reached approval. The name is also used loosely for a related peptide without DAC (modified GRF 1-29), which is a different molecule.
Evidence listed here
- 2 human studies
- 1 animal study
Results from cells and animals often don't carry over to people. How to read peptide research
Molecular info
- Class
- Synthetic peptide (GHRH analog)
- Length
- 30 amino acids
- Sequence
- H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)-NH2
- Research areas
- Growth hormone
The last lysine carries the DAC linker (maleimidopropionyl), which binds albumin in the blood.
Research
- Human studyGrowth Horm IGF Res · 2009Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects.
Blood protein profile changes in healthy adults in a CJC-1295 trial.
- Human studyJ Clin Endocrinol Metab · 2006Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Randomized placebo-controlled trials in healthy adults measuring GH and IGF-1.
- Animal studyAm J Physiol Endocrinol Metab · 2006Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.
Growth in GHRH-knockout mice.