DSIP
Also called Delta sleep-inducing peptide, Emideltide
Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use DSIP or any amount of it. Talk to a clinician.
Not approved as a medicine by the FDA or EMA (as of October 2026).
Research applications
- Slow-wave (delta) sleep (early animal studies)
- Chronic insomnia (small controlled human studies with inconsistent results)
What studies have looked at, not proven uses.
What it is
DSIP is a small peptide discovered in the 1970s and named for its link to deep sleep in animals. Human sleep studies had mixed results, and how it works is still unclear.
More detail
Delta sleep-inducing peptide (DSIP) is a nine-amino-acid peptide first isolated in the 1970s from the blood of rabbits in induced sleep, and named for its reported ability to increase slow-wave (delta) sleep in those animals. Decades later, its natural role, its receptor and how the body makes it remain unclear. Small controlled studies in the 1980s and early 1990s looked at sleep in people with chronic insomnia, with inconsistent results: one reported clear improvement, while a later double-blind study concluded the effects were weak. Reviews describe many reported effects in animals but little consistent evidence. Recent research on DSIP is limited.
Evidence listed here
- 2 human studies
- 1 review
Results from cells and animals often don't carry over to people. How to read peptide research
Molecular info
- Class
- Nonapeptide
- Length
- 9 amino acids
- Sequence
- H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
- Research areas
- Sleep
Research
- Human studyNeuropsychobiology · 1992Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study.
Double-blind study in 16 people with chronic insomnia.
- Human studyEur Neurol · 1987Effects of delta-sleep-inducing peptide on 24-hour sleep-wake behaviour in severe chronic insomnia.
Placebo-controlled study of sleep and daytime function in chronic insomnia.
- ReviewPeptides · 1986Delta-sleep-inducing peptide (DSIP): an update.
Review of DSIP research up to the mid-1980s.