Epitalon
Also called Epithalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly
Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use Epitalon or any amount of it. Talk to a clinician.
News · October 30, 2026
Draft HHS policy on compounding
On Oct 30, 2026, HHS said it won't act against licensed pharmacies that compound certain peptides while the FDA reviews them. News reports say the list includes BPC-157, KPV, TB-500, MOTS-c, Epitalon and Semax. It's a draft, not FDA approval.
Not approved as a medicine by the FDA or EMA (as of October 2026).
Research applications
- Telomerase and telomere length (cell studies, including human cell lines)
- Lifespan (rodent and fruit fly studies)
- Tumour development (rodent studies)
- Small, older human studies, many on the parent pineal extract
What studies have looked at, not proven uses.
What it is
Epitalon is a lab-made peptide of four amino acids, developed in Russia. Most research comes from one lab, in animals and cells, looking at aging. Human data are very limited.
More detail
Epitalon is a synthetic four-amino-acid peptide (alanine, glutamic acid, aspartic acid, glycine). It was developed in Russia, based on the amino-acid makeup of epithalamin, an extract of bovine pineal gland. Much of the research comes from one research group in St. Petersburg and includes lifespan and tumour studies in rodents and fruit flies, plus cell studies on telomerase, the enzyme that maintains the protective ends of chromosomes. A 2025 study in human cell lines reported longer telomeres. Human data are sparse and come mostly from older, small studies, many of them on the parent extract, so the evidence base is largely animal and laboratory work.
Evidence listed here
- 1 review
- 1 animal study
- 1 lab (cell) study
Results from cells and animals often don't carry over to people. How to read peptide research
Molecular info
- Class
- Synthetic tetrapeptide
- Length
- 4 amino acids
- Sequence
- H-Ala-Glu-Asp-Gly-OH
- Research areas
- Longevity
Research
- ReviewInt J Mol Sci · 2025Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
Overview of in vitro, animal and in silico research on epitalon.
- Animal studyBull Exp Biol Med · 2007Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.
Lifespan and spontaneous tumours in female rats under different light regimes.
- Cell / lab studyBiogerontology · 2025Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.
Telomere length and telomerase in human cell lines.