Kisspeptin-10

Also called KP-10, Kisspeptin 10, Metastin (45-54)

Studied in:Sexual health

Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use Kisspeptin-10 or any amount of it. Talk to a clinician.

Not approved as a medicine by the FDA or EMA (as of October 2026).

Research applications

LH and FSH release through GnRH neurons (controlled studies in volunteers)
Responses across the menstrual cycle (studies in women)
Puberty and fertility signalling
Diagnosing and treating reproductive disorders (academic research)

What studies have looked at, not proven uses.

What it is

Kisspeptin-10 is a short form of kisspeptin, a natural hormone that switches on the body's reproductive hormones. It's studied mainly in academic research on fertility.

More detail

Kisspeptin-10 is the shortest fully active form of kisspeptin, a hormone made from the KISS1 gene, and consists of the last ten amino acids of the larger protein. Kisspeptin acts on its receptor in the brain to switch on GnRH neurons, which drive release of the reproductive hormones LH and FSH, and it plays a central role in puberty and fertility. Controlled studies in healthy volunteers measured strong LH responses in men, while in women responses depended on the phase of the menstrual cycle. Kisspeptin is being researched, mostly in academic studies, as a tool for diagnosing and treating reproductive disorders.

Evidence listed here

2 human studies
1 review

Results from cells and animals often don't carry over to people. How to read peptide research

Molecular info

Class: Peptide hormone fragment
Length: 10 amino acids
Sequence: H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Research areas: Sexual health

The last ten amino acids of kisspeptin, ending in an amide.