Selank
Also called TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Tuftsin analog
Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use Selank or any amount of it. Talk to a clinician.
Approved as a medicine in Russia for anxiety, according to a 2026 published review; not approved by the FDA or EMA (as of October 2026).
Research applications
- Anxiety disorders (small Russian clinical studies)
- GABA-related genes and enkephalin breakdown (lab and rat studies)
- Anxiety-like behaviour (rat studies)
What studies have looked at, not proven uses.
What it is
Selank is a lab-made peptide developed in Russia, based on a small immune-system peptide. It has been studied in small Russian trials for anxiety. Large independent trials are lacking.
More detail
Selank is a synthetic seven-amino-acid peptide based on tuftsin, a short peptide from the immune system, with a Pro-Gly-Pro tail added for stability. It was developed in Russia. Laboratory and rat studies have examined its effects on genes linked to GABA signalling, on enzymes that break down enkephalins, and on anxiety-like behaviour. Human evidence consists of a small number of Russian clinical studies in people with generalized anxiety disorder and neurasthenia that compared it with benzodiazepine-type medicines; these were small and published mainly in Russian. Large independent trials have not been reported.
Evidence listed here
- 1 human study
- 1 animal study
- 1 lab (cell) study
Results from cells and animals often don't carry over to people. How to read peptide research
Molecular info
- Class
- Synthetic peptide (tuftsin analog)
- Length
- 7 amino acids
- Sequence
- H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH
- Research areas
- Mood and stress
Tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro tail added for stability.
Research
- Human studyZh Nevrol Psikhiatr Im S S Korsakova · 2008[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia].
Comparison with medazepam in generalized anxiety disorder and neurasthenia (Russian).
- Animal studyFront Pharmacol · 2016Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.
Gene expression in the rat frontal cortex after administration.
- Cell / lab studyFront Pharmacol · 2017GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.
Gene expression in human neuroblastoma (IMR-32) cells.