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Peptides

Sermorelin

Also called Sermorelin acetate, GRF 1-29, GHRH (1-29), Geref

Studied in:Growth hormone

Educational only, not medical advice. Dosaly reports what has been studied; it isn't a recommendation to use Sermorelin or any amount of it. Talk to a clinician.

Previously approved by the FDA as Geref (sermorelin acetate), now discontinued; no sermorelin product is currently marketed in the US under an FDA approval, and it is not approved by the EMA (as of October 2026).

Research applications

  • Testing pituitary growth hormone function (formerly approved diagnostic use)
  • Growth hormone deficiency in children (clinical trials)
  • Growth hormone, IGF-1 and muscle measures in older men (small studies)

What studies have looked at, not proven uses.

What it is

Sermorelin is a lab-made copy of part of the hormone that tells the body to release growth hormone. It was once FDA-approved for children with growth hormone deficiency, then discontinued.

More detail

Sermorelin is a synthetic copy of the first 29 amino acids of human growth hormone-releasing hormone (GHRH), the shortest fragment that keeps the full activity of the natural hormone. It acts on the pituitary to release growth hormone. It was approved in the United States in the 1990s under the brand Geref, for testing pituitary growth hormone function and for treating children with idiopathic growth hormone deficiency, after clinical trials in children. Small studies in healthy older men looked at growth hormone, IGF-1 and muscle measures. The branded product was later discontinued, and newer controlled research on sermorelin is limited.

Evidence listed here

  • 1 human study
  • 1 review

Results from cells and animals often don't carry over to people. How to read peptide research

Molecular info

Class
Synthetic peptide (GHRH 1-29)
Length
29 amino acids
Sequence
H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Research areas
Growth hormone

The first 29 amino acids of human growth hormone-releasing hormone, ending in an amide.